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Lipitor (atorvastatin)

Brand name: Lipitor
Generic name: Atorvastatin.

While using Lipitor: inhibition of Coenzyme Q10 synthesis along with possible depletion of vitamin D may occur. If using this prescription drug to lower your cholesterol, you need:
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Lipitor blocks the production of cholesterol (a type of fat) in your body. Lipitor is used to reduce the amounts of LDL (bad) cholesterol, total cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in your blood. Lipitor is also used to increase the level of HDL (good) cholesterol in your blood. These actions are important in reducing the risk of hardening of the arteries, which can lead to heart attacks, stroke, and peripheral vascular disease.

Minimize the potential side effects of nutrient deficiencies by using NutraMD High Cholesterol Essential Nutrients® supplements.

Atorvastatin is an oral drug that lowers the level of cholesterol in the blood. It belongs to a class of drugs referred to as statins. All statins, including atorvastatin, prevent the production of cholesterol by the liver by blocking the enzyme that makes cholesterol, HMGCoA reductase. They lower total blood cholesterol as well as LDL cholesterol levels. (LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease.) Lowering LDL cholesterol levels retards progression and may even reverse coronary artery disease. Unlike the other drugs in this class, atorvastatin also can reduce the concentration of triglycerides in the blood. High blood concentrations of triglycerides also have been associated with coronary artery disease.

High cholesterol medical health information:
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References:

  1. Bliznakov EG.  Coenzyme Q10, Lipid-Lowering Drugs (Statins) and Cholesterol:  A Present Day Pandora’s Box.  Physcians should consider the potential for drug-nutrient depletion.  JANA 2002; 5(3): 32-38.
  2. De Pinieux G, Chariot P, et al.  Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.  Br J Clin Pharmacol 1996; 42: 333-37.
  3. Mortensen SA, Leth A, et al.  Dose-related Decrease of Serum Coenzyme Q10 During Treatment with HMG-CoA Reductase Inhibitors.  Molec Aspests Med 1997; 18(suppl): s137-s144.
  4. Ghirlanda G, Oradei A, et al.  Evidence of Plasma CoQ10 Lowering Effect by HMG-CoA Reductase Inhibitors: A Double-Blind, Placebo-Controlled Study.  J Clin Pharmacol 1993; 33:226-229.
  5. Strey CH, Young JM, et al.  Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure.  Atherosclerosis 2005; 179:201-206.