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Crestor (rosuvastatin)

Brand name: Crestor
Generic name: Rosuvastatin

While using Crestor: depletion or interference with Coenzyme Q10 and vitamin D may occur.
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Crestor is used to lower cholesterol levels when diet and exercise alone have failed to work. The drug can help lower the total cholesterol count as well as harmful levels of low-density lipoprotein (LDL) cholesterol. It can also lower triglycerides, a type of fat that is carried through the bloodstream and can end up being stored as body fat.

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Rosuvastatin is an oral drug for lowering blood cholesterol levels. It belongs to a class of drugs called HMG-CoA reductase inhibitors, more commonly referred to as "statins". These drugs reduce cholesterol levels by inhibiting HMG-CoA reductase, an enzyme that produces cholesterol in the liver. Rosuvastatin and other statins lower blood total cholesterol as well as blood LDL cholesterol levels. LDL cholesterol is the "bad" type of cholesterol that increases the risk of coronary artery disease (atherosclerosis) and heart attacks. Lowering LDL cholesterol levels slows the progression of coronary artery disease and may even reverse it. Statins also increase HDL cholesterol, the "good" type of cholesterol, and reduce triglycerides.

High cholesterol medical health information:
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References:

  1. Bliznakov EG.  Coenzyme Q10, Lipid-Lowering Drugs (Statins) and Cholesterol:  A Present Day Pandora’s Box.  Physcians should consider the potential for drug-nutrient depletion.  JANA 2002; 5(3): 32-38.
  2. De Pinieux G, Chariot P, et al.  Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.  Br J Clin Pharmacol 1996; 42: 333-37.
  3. Mortensen SA, Leth A, et al.  Dose-related Decrease of Serum Coenzyme Q10 During Treatment with HMG-CoA Reductase Inhibitors.  Molec Aspests Med 1997; 18(suppl): s137-s144.
  4. Ghirlanda G, Oradei A, et al.  Evidence of Plasma CoQ10 Lowering Effect by HMG-CoA Reductase Inhibitors: A Double-Blind, Placebo-Controlled Study.  J Clin Pharmacol 1993; 33:226-229.
  5. Strey CH, Young JM, et al.  Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure.  Atherosclerosis 2005; 179:201-206.